Collagen-Induced Arthritis Inhibition of Fractalkine Ameliorates Murine

Inhibition of microRNA-34a ameliorates murine collagen-induced arthritis

Rheumatoid arthritis (RA) is one of the most frequently occurring autoimmne diseases, with symptoms including synovium hyperplasia, immune disorder, cartilage damage and bone resorption. It has previously been demonstrated that microRNA-34a (miR-34a) may participate in cell apoptosis, immune activation and bone metabolism, therefore the present study investigated the effects of miR-34a on RA. C...

Adenoviral transfer of cyclin-dependent kinase inhibitor genes suppresses collagen-induced arthritis in mice.

In rheumatoid synovial tissues, synovial fibroblasts are activated by proinflammatory cytokines and proliferate to develop hyperplastic pannus tissues, which irreversibly damage the affected joints. We recently reported that the cyclin-dependent kinase inhibitors p16(INK4a) and p21(Cip1) are not expressed in vivo in rheumatoid synovial fibroblasts, but are readily inducible in vitro. This obser...

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.

There is considerable evidence implicating tumor necrosis factor alpha (TNF-alpha) in the pathogenesis of rheumatoid arthritis. This evidence is based not only on the universal presence of TNF-alpha in arthritic joints accompanied by the upregulation of TNF-alpha receptors but also on the effects of neutralizing TNF-alpha in joint cell cultures. Thus, neutralization of TNF-alpha in vitro result...

IL-1ab Blockade Prevents Cartilage and Bone Destruction in Murine Type II Collagen-Induced Arthritis, Whereas TNF-a Blockade Only Ameliorates Joint Inflammation

Synovial fractalkine plays important role in cytokines’ related knee edema variation in rat arthritis model

Introduction: The systemic and local content of inflammatory cytokines and chemokines play substantial roles in pathophysiology of arthritis. This study was purposed to verify the roles of synovial TNF-α, IL-6 and fractalkine (Fkn) in edema changes during different stages of Complete Freund’s Adjuvant (CFA)-induced knee arthritis in rats. Methods: 168 male Wistar rats were divided i...